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These features make GLP-1 RAs an advantageous alternative to rapid-acting insulin for patients inadequately controlled on a long-acting basal insulin

The enzyme-catalyzed reverse reaction between GSSG or GSSR and reduced roGFP2 releases roGFP2(SSG) which can instantaneously react via a nonenzymatic shortcut yielding GSH and roGFP2(S 2 ) (Fig

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Prevention is better than aftercare

Assessments were conducted by a paediatric neurophysician who was blinded to dietary intervention status

Based on published Phase 2 trial data, the most common adverse events are gastrointestinal: nausea (up to 46%), diarrhea (up to 33%), vomiting (up to 22%), and decreased appetite (up to 22%)